Searchable abstracts of presentations at key conferences in endocrinology

ea0013p246 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

A subnormal peak cortisol response to stimulation testing does not predict a subnormal cortisol production rate (CPR)

Paisley Angela , Rowles Susannah , Roberts Margaret , Brandon David , Trainer Peter

In patients with pituitary disease stimulation tests, such as the insulin tolerance test, are performed as tests of the HPA axis and widely used as the basis for commencing hydrocortisone replacement therapy.We conducted a pilot study to investigate the relationship between the peak cortisol response to insulin-induced hypoglycaemia and daily CPR. Isotopic CPRs were studied in 10 patients (5 male, mean age 44±13 years) with pituitary disease and a s...